EDITORIAL COMMENT
Despite the negative results of studies comparing cholinesterase inhibitors to placebo in amnestic MCI (Gauthier & Touchon, see the FAXBACK section), there is a major interest in studying the biological correlates of MCI subtypes (Bell-McGinty et al ) and the benefit of a structural cognitive training program (Belleville et al ).

Differential cortical atrophy in subgroups of mild cognitive impairment
(ARCH NEUROL 2005;62:1393-1397)

SANDRA BELL-MCGINTY, PHD,
OSCAR L. LOPEZ, MD,
CAROLYN CIDIS MELTZER, MD,
JOELLE M. SCANLON, PHD,
ET AL,
PITTSBURGH, PA

Cognitive improvement and neural substrate of memory intervention in persons with mild cognitive impairment
(INTERNATIONAL PSYCHOGERIATRICS 2005;17:SUPPL 2)

SYLVIE BELLEVILLE,
BRIGITTE GILBERT,
SAMIRA MELLAH,
SOPHIE FONTAINE,
ET AL,
MONTREAL, QC

NATURAL HISTORY OF PRIMARY PROGRESSIVE APHASIA

EDITORIAL COMMENT
One of the largest research units on frontotemporal dementia (FTD), based in Lille, France, has previously reported benefit from trazodone in this condition. These investigators now report on the high number of persons with primary progressive aphasia who progress towards FTD (Le Rhun et al ).

Natural history of primary progressive aphasia
(NEUROLOGY 2005;65:887-891)

EMILIE LE RHUN, MD,
FLORENCE RICHARD, MD, PHD,
FLORENCE PASQUIER, MD, PHD
LILLE, FRANCE