|
There is increasing evidence that small-vessel
disease caused by high blood pressure in mid-life (Qiu et al
) leads to white matter changes on MRI and non-memory cognitive
decline affecting information processing speed and executive function
(Prins et al ). When the functional threshold for vascular
dementia had been reached, donepezil was found effective in the
combined analysis run by Román et al from two large
pivotal placebocontrolled studies.
The age-dependent relation of blood
pressure to cognitive function and dementia
(LANCET NEUROL 2005;4:487-499)
CHENGXUAN QIU,
BENGT WINBLAD,
LAURA FRATIGLIONI
STOCKHOLM, SWEDEN
Cerebral small-vessel disease and decline
in information processing speed, executive function and memory
(BRAIN 2005;128:2034-2041)
NIELS D. PRINS,
EWOUD J. VAN DIJK,
TOM DEN HEIJER,
SARAH E. VERMEER,
ET AL,
ROTTERDAM,
MAASTRICHT, THE NETHERLANDS
Donepezil in vascular dementia: combined
analysis of two large-scale clinical trials
(DEMENT GERIATR COGN DISORD 2005;20:338-344)
GUSTAVO C. ROMÁN,
DAVID G, WILKINSON,
RACHELLE S. DOODY,
SANDRA E. BLACK,
ET AL
SAN ANTONIO, HOUSTON, TX
NEW YORK, NY,
SOUTHAMPTON, UK,
|
