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The usefulness of in vivo amyloid
brain imaging using the “Pittsburgh Compound B” is
being carefully assessed as it could contribute to very early
diagnosis of AD (see previous section). Lockhart et al
demonstrate that PIB binds to classical plaques and delineates
diffuse plaques as well as cerebrovascular amyloid angiopathy.
This is confirmed by Johnson et al (see the FAX back
section) and a supportive editorial by Harry Vinters (Annals
Neurol 2007;62:209-211). Clinical usefulness for diagnosis
of AD has been studied by Ng et al in atypical dementia
syndromes.
PIB is a non-specific imaging marker
of amyloid-beta (Aß) peptide-related cerebral amyloidosis
(Brain 2007;130:2607-2615)
A. Lockhart ,
J.R. Lamb,
T. Osredkar,
L.I. Sue,
et al
Essex, UK,
Midlothian, UK,
Phoenix, AZ,
Basel, Switzerland
Evaluating atypical dementia syndromes
using positron emission tomography with carbon 11–labeled
Pittsburgh Compound B
(Arch Neurol 2007;64:[8]1140-1144)
Steven Y. Ng, MBBS,
Victor L. Villemagne, MD,
Colin L. Masters, MD,
Christopher C. Rowe, MD
Melbourne, Australia
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