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An expert group led by Bruno Dubois has
proposed a new set of diagnostic criteria for AD. These would
allow for earlier diagnosis when cognitive impairment is limited
to episodic memory with supportive evidence from at least one
“biomarker” using either brain imaging, cerebrospinal
fluid examination or genetic testing. The earlier “pre-dementia”
diagnosis of AD would allow for therapeutic research at a stage
when there may be more reversibility to the pathology (cell
death, inflammation, amyloid deposition, NFT intracellular accumulation).
The risk is that very early diagnosis may be associated with
reactive depression, requiring the type of supervision discussed
by Fisk et al in their article on disclosure of the diagnosis
of dementia.
Research criteria for the diagnosis
of Alzheimer’s disease: revising the NINCDS-ADRDA criteria
(Lancet Neurol 2007;6[8]:734-746)
Bruno Dubois,
Howard H. Feldman,
Claudia Jacova,
Steven T. Dekosky,
et al,
Various centres
Disclosure of the diagnosis of dementia
(Alzheimer’s and Dementia
2007;3[4]:404-410)
| this abstract is unavailable |
John D. Fisk,
B. Lynn Beattie,
Martha Donnelly,
Anna Byszewski,
et al,
Halifax, NS
Vancouver, BC
Ottawa, ON
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