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NEW DIAGNOSTIC CRITERIA
FOR AD BEFORE DEMENTIA
AMYLOID IMAGING USING
PET IS GAINING MORE CREDIBILITY
- PIBs are limited for monitoring AD progression
- C-PIB may have a place in diagnosing atypical
dementia
EFFICACY OF DONEPEZIL
IN SEVERE AD
- Donepezil is effective in patients with
severe AD
- Guidelines are needed for AD patient and
caregiver alike
CHOLINESTERASE INHIBITORS
AND MEMANTINE IN VASCULAR DEMENTIA
- CIs and memantine have limited effects
in vascular dementia
- More research into cognitive decline due
to vascular etiology is warranted
PHARMACOLOGICAL MANAGEMENT
OF NEUROPSYCHIATRIC SYMPTOMS
- Safer treatments are needed for neuropsychiatric
symptoms
- Donepezil is equal to placebo in AD patients
with agitation
- Conventional and atypical antipsychotics
may raise femur-fracture risk
- Antipsychotic medications are associated
with increased mortality in dementia
- Citalopram and risperidone were equally
effective for agitation and psychosis in dementia
DONEPEZIL FOR FRONTOTEMPORAL
DEMENTIA
- Treatment with donepezil showed no changes
in cognitive performance in FTD patients
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