IN THIS ISSUE MARCH 2007
PREVENTION OF ALZHEIMER’S DISEASE
  • Fruit and vegetable juices may delay onset of AD
  • Exercise program slows decline in activities of daily living score among patients with AD
  • Cognitive training brings sustained improvement in cognitive abilities
  • Proven home-based clinical information gathering instrument eases burden on prevention trials

AMYLOID AND ALZHEIMER’S DISEASE

  • [11C]PIB amyloid imaging may help detect preclinical AD
  • Amyloid imaging and CSF Aß42 may serve as biomarkers of preclinical AD
  • 3APS is safe, tolerated and reduces CSF Aß42 levels in patients with
  • mild-to-moderate AD

MEMANTINE FOR MILD-TO-MODERATE AD

24-week RCT shows memantine safe and effective in mild-to-moderate AD

ATYPICAL ANTIPSYCHOTICS: CONCERNS ABOUT EFFICACY AND SAFETY

  • Adverse effects offset benefits of atypical antipsychotics used in patients with AD
  • Atypical antipsychotics associated with potentially serious adverse events

CAREGIVER FOCUS IN DEMENTIA MANAGEMENT

  • Support for caregivers delays nursing home placement of AD patients
  • Guideline-based disease management program improves quality of care for dementia patients
 

 

 

 

 

 

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SERGE G. GAUTHIER, MD, FRCPC, received his medical degree from the University of Montreal in 1973. Following post-graduate studies in neurology at McGill University, he obtained certification in neurology for Quebec and Canada in 1977 and for the USA in 1983. From 1977 to 1985 he was on the attending staff at the Montreal Neurological Institute, and from 1986 to 1997, he was Director of the McGill Centre for Studies in Aging. He currently holds a Research Chair of the MRC/PMAC Health Program, and is Professor in the Departments of Neurology and Neurosurgery, Psychiatry and Medicine at McGill University.
NATHAN HERRMANN, MD, FRCPC, obtained his Doctorate of Medicine Degree from the University of Toronto in 1983 and completed the Psychiatry Residency Program at the University of Toronto in 1988. He is currently a Professor in the Department of Psychiatry at the University of Toronto and heads the University’s Division of Geriatric Psychiatry. He is a Staff Psychiatrist and Head of the Division of Geriatric Psychiatry at Sunnybrook & Women’s College Health Sciences Centre and is cross-appointed as Professor in the Department of Medicine in the Division of Clinical Pharmacology.
International Abstracts in Alzheimer’s Disease &Other Dementias monitors and reports on the significant studies and developments in the diagnosis, etiology, natural history and treatment of this condition. Journals from which the abstracts are drawn include: ALZHEIMER DISEASE AND ASSOCIATED DISORDERS (Alzheimer Dis); AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (Am J Geriatr Psychiatry); AMERICAN JOURNAL OF PSYCHIATRY (Am J Psychiatry); ANNALS OF NEUROLOGY (Ann Neurol); ARCHIVES OF NEUROLOGY (Arch Neurol); BRAIN (Brain); BRITISH MEDICAL JOURNAL (BMJ); CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES (Can J Neurol Sci); EUROPEAN NEUROLOGY (Eur Neurol); INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (Int J Geriat Psychiatry); INTERNATIONAL PSYCHOGERIATRICS; JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (J Am Geriatr Soc); JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (JAMA); JOURNAL OF CLINICAL PSYCHIATRY (J Clin Psychiatry); JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (J Neurol Neurosurg Psychiatry); LANCET (Lancet); NEW ENGLAND JOURNAL OF MEDICINE (N Engl J Med); NEUROLOGY (Neurology).
 
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