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Although cerebrospinal fluid (CSF) examination
is not routinely performed in Canada for the assessment of dementia,
there is building evidence for the ability of certain markers
to predict AD in older adults with (Simonsen et al) or
without symptoms (Fagan et al ). There will be publications
later this year calling for an update of the diagnostic criteria
for AD to include the pre-dementia stage, using brain imaging
and CSF findings as supportive evidence. We may need to use
our needles!
Novel panel of cerebrospinal fluid
biomarkers for the prediction of progression to Alzheimer dementia
in patients with mild cognitive impairment
(Arch Neurol 2007;64:366-370)
a.h. Simonsen,
j. McGuire,
o. Hanson,
h. Zetterberg,
et al
Copenhagen, Denmark
Cerebrospinal fluid tau/β-amyloid42
ratio as a prediction of cognitive decline in nondemented older
adults
(Arch neurol 2007;64)
a.m. Faga n,
c.m. Roe,
c. Xiong,
m.a. Mintun,
j.c. Morris,
et al
St Louis, MO
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