Mild cognitive impairment continues to
be of great interest as a potential prodrome (pre-dementia)
stage of AD and other dementias. The International Psychogeriatric
Association (IPA) published a review on this topic (Gauthier
et al ), and two studies give valuable data over three years
(Tschanz et al ) and 10 years data (Visser et al, see Faxback
section).
Mild cognitive impairment
(LANCET 2006;367:1262-1270)
SERGE GAUTHIER,
BARRY REISBERG,
MICHAEL ZAUDIG,
RONALD C PETERSEN,
ET AL,
VARIOUS INT’L CENTRES
on behalf of the participants
of the international
psychogeriatric association
expert conference on mild
cognitive impairment
Conversion to dementia from mild
cognitive disorder: the Cache County Study
(NEUROLOGY 2006;67:229-234)
J.T. TSCHANZ, PhD,
K.A. WELSH-BOHMER, PhD,
C.G. LYKETSOS, MD, MHS,
C. CORCORAN, PhD,
ET AL,
VARIOUS CENTRES, USA
and the cache county
investigators
BODY WEIGHT AND COGNITIVE
IMPAIRMENT
Higher body mass index is associated with
impaired cognitive function in mid-life (Cournot et al ), and
obesity is a risk factor for dementia in late life (Whitmer
& Yaffe, see Faxback section), but weight loss may precede
the diagnosis of AD (Johnson et al). As is the case for systolic
hypertension, weight as a risk factor for AD needs to be studied
over the full span of adult life.
Relation between body mass index and cognitive function
in healthy middle-aged men and women
(NEUROLOGY 2006;67:1208-1214)
M. COURNOT, MD,
J.-C. MARQUIé, PhD,
D. ANSIAU, PhD,
C. MARTINAUD, MD,
ET AL,
TOULOUSE, FRANCE
Accelerated weight loss may precede diagnosis
in Alzheimer disease
(ARCH NEUROL. 2006;63:1312-1317)
DAVID K. JOHNSON, PhD,
CONSUELO H. WILKINS, MD,
JOHN C. MORRIS, MD
ST. LOUIS, MO
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