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Mild cognitive impairment (MCI) is getting
increasing attention. The ‘amnestic’ subtype (aMCI)
is considered by many as a prodromal (or pre-dementia) stage of
AD: this is supported by the CSF and MRI findings reported by
de Leon et al. Cohort studies now allow assessment of risk
and protective factors for aMCI, as found in Verghese et al.
Another important sub-type is multiple impaired cognitive domains
(mcd-MCI) which was found by Zanetti et al to be a prodrome
to subcortical vascular dementia.
Longitudinal csf and mri biomarkers
improve the diagnosis of mild cognitive impairment
(NEUROBIOLOGY OF AGING 2006;27:394-401)
M.J. DE LEON,
S. DESANTI,
R. ZINKOWSKI,
P.D. MEHTA,
ET AL,
VARIOUS CENTRES, USA,
MUNICH, GERMANY,
STOCKHOLM, SWEDEN
Leisure activities and the risk of
amnestic mild cognitive impairment in the elderly
(NEUROLOGY 2006;66:821-827)
J. VERGHESE, MD,
A. LEVALLEY, MA,
C. DERBY, PhD,
G. KUSLANSKY, PhD,
ET AL,
Bro nx, ny,
orlando, fl
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