Feb 1999
international
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Feb 1999 international |
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alzheimer's issues: february 2003 november 2002 august 2002 may 2002 february 2002 november 2001 august 2001 may 2001 february 2001 november 2000 august 2000 june 2000 march 2000 november 1999 may 1999 february 1999 september 1998 june 1998 march 1998 december 1997 |
IN THIS ISSUEMINIMAL COGNITIVE
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| EDITORIAL FOREWORD |
MINIMAL COGNITIVE IMPAIRMENTThere is currently a major effort to delay progression from Minimal Cognitive Impairment (MCI) to dementia. The natural history of this progression has been extensively studied by various groups in the US (Grundman et al) and Canada (Tierney et al), and now offers a way to test the hypothesis that anti-oxydants such as tocopherol, cholinesterase inhibitors such as donepezil and rivastigmine, and COX-2 selective inhibitors can delay progression of AD by modification of primary or secondary disease mechanisms. More articles on MCI can be found in the FAX-back section. |
| M. GRUNDMAN, R.C. PETERSEN, J.C. MORRIS, S. FERRIS, ET AL, VARIOUS CENTRES, US |
SORRY, THIS ABSTRACT IS UNAVAILABLE |
| M.C. TIERNEY, PHD, J.P. SZALAI, PHD, W.G. SNOW, PHD, R.H. FISHER, MB, ET AL, TORONTO, ON |
| EDITORIAL COMMENT |
Evidence for interhemispheric disconnection through the corpus
callosum has been found in AD, using a neuropsychological approach (Lakmache
et al) as well as brain imaging with MRI (Teipel et al).
This may offer another early differentiating tool versus normal aging, and
add to the understanding of complex cognitive processing between cerebral
hemispheres. |
| YAMINA LAKMACHE, MARYSE LASSONDE, SERGE GAUTHIER, JEAN-YVES FRIGON, FRANCO LEPORE, MONTREAL, QC |
| S.J. TEIPEL, MD, H. HAMPEL, MD, G.E. ALEXANDER, PHD, M.B. SCHAPIRO, MD, ET AL, MUNICH, GERMANY, BETHESDA, MD |
| EDITORIAL COMMENT |
Recent reports have documented again the impact of non-cognitive
disturbances on caregivers (Victoroff et al). Suggestions have
thus been made for symptom-led interventions (Donaldson et al).
Homecare support was found to be underused in germany (Vetter et al)
as was the case in Canada during the Study of Health and Aging of 1991 (Can
J on Aging, 1994;13:470-487). |
| JEFF VICTOROFF, WENDY J. MACK, KRISTY A. NIELSON, LOS ANGELES, IRVINE, DOWNEY, CA |
| C. DONALDSON, N. TARRIER, A. BURNS, MANCHESTER, UK |
| P. VETTER, O. STEINER, S. KRAUS, H. MOISES, ET AL, BERLIN, GERMANY |
| EDITORIAL COMMENT |
A number of reports have been recently published on FTD, originally
known as Pick's disease (hence the expression "take your pick" in TD Bird's
editorial, Neurology 1998;50:1526-1527, commenting on the observation
by Lendon et al on the link between FTD and a mutation on chromosome 17).
The clinical features differentiating FTD from AD have been summarized by
J. Cummings at the Amsterdam meeting and the Lund-Manchester research diagnostic
criteria (originally published in J Neurol Neurosurg Psychiatry
1994;57:416-418) appear to be useful in imaging studies comparing FTD and
AD (Miller et al). |
| C.L. LENDON, PHD, T. LYNCH, MD, J. NORTON, RN, D.W. MCKEEL, JR, MD, ET AL, VARIOUS CENTRES US |
| J.L. CUMMINGS, LOS ANGELES, CA |
SORRY, THIS ABSTRACT IS UNAVAILABLE |
| B.L. MILLER, MD, C. IKONTE, BS, M. PONTON, PHD, M. LEVY, MD, ET AL, LOS ANGELES, CA, SANTIAGO, CHILI |
| EDITORIAL COMMENT |
A reversible cause of dementia is very rarely found in routine
computer tomography, as documented by Freter et al, hence the importance
of a good history and serial follow-up. |
| SUSAN FRETER, MD, HOWARD BERGMAN, MD, SUSAN GOLD, MD, HOWARD CHERTKOW, MD, MARK CLARFIELD, MD, MONTREAL, QC |
