Dec 1997
international
abstracts:
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Dec 1997 international |
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alzheimer's issues: february 2003 november 2002 august 2002 may 2002 february 2002 november 2001 august 2001 may 2001 february 2001 november 2000 august 2000 june 2000 march 2000 november 1999 may 1999 february 1999 september 1998 june 1998 march 1998 december 1997 |
IN THIS ISSUEDIFFERENTIAL DIAGNOSIS OF ALZHEIMER'S DISEASE
NATURAL HISTORY OF ALZHEIMER'S DISEASE
TREATING ALZHEIMER'S
MISCELLANEOUS
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| EDITORIAL FOREWORD | It is with great pleasure that I welcome you to the
first issue of International Abstracts on Alzheimer's Disease.
I plan to update readers on recent advances in the research on the causes
and treatments of Alzheimer's disease (AD). Such an initiative is timely
as new medications for the symptomatic treatment of AD are becoming available
for general prescription use. This will increase the interest in early diagnosis
and provide impetus for improvement in disease management at all stages
of disease progression. This first issue will look at highlights of recently
published reports on differential diagnosis, natural history and treatments
of AD. Additional abstracts are available from the FAX-back section. |
| EDITORIAL COMMENT: | The article by Gelbacher and Whitehouser, from a
supplement of Neurology, edited by S. DeKosky on Managing Alzheimer's disease,
is a short and well-referenced review of diagnostic issues in AD. There
are also recent publications on the differentiation between AD and cortico-basal
ganglionic degeneration (Schneider et al), and from Pick's disease (Litvan
et al). |
(NEUROLOGY 1997;48(SUPPL 6):S2-S9)
| DAVID S.
GELDMACHER, MD, PETER J. WHITEHOUSE, Jr, MD, PHD, CLEVELAND, OH |
To view abstract in
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(NEUROLOGY 1997;48:959-969)
| J.A. SCHNEIDER, MD, R.L. WATTS, MD, M. GEARING, PHD, R.P. BREWER, MD, S.S. MIRRA, MD, ATLANTA, GA |
To view abstract in
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(NEUROLOGY 1997;49:62-69)
| I. LITVAN, MD, Y. AGID, MD, PHD, N. SASTRJ, BS, J. JANKOVIC, MD, ET AL, PARIS, FRANCE, LONDON, UK, VARIOUS CENTRES, USA |
To view abstract in
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| EDITORIAL COMMENT: | There is great interest in knowing the natural history
of AD, vascular disease and mixed dementia, as new treatments are being
tested to slow down the expected decline. Bowler et al report on
the University of Western Ontario registry, whereas Clark et al
and Heyman et al report from the CERAD data base. A canadian initiative
led by Drs Howard Feldman and Ken Rockwood is also building a country-wide
data base, under the MRC/PMAC Health Program funded ACCORD project. |
(ARCH NEUROL 1997;54:697-703)
| JOHN V. BOWLER,
MB, MD, MRCP, MICHAEL ELIASZIW, PHD, RUNA STEENHUIS, PHD, DAVID G. MUNOZ, MD, FRCPC, ET AL, LONDON, ON |
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NEUROLOGY 1997;49:70-75)
| C.M. CLARK, MD, D. EWBANK, PHD, A. LERNER, MD, R. DOODY, MD, PHD, ET AL, AND THE CERAD COLLABORATORS, VARIOUS CENTRES, USA |
To view abstract in
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(NEUROLOGY 1997;48:1304-1309)
| A. HEYMAN, MD, B. PETERSON, PHD,G. FILLENBAUM, PHD,C. PIEPER, DRPH, DURHAM, NC |
To view abstract in
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| EDITORIAL COMMENT: | Using the activities of daily living (ADL) domains
of the Clinical Dementia Rating scale, Friedhoff and Rogers found that the
cholinesterase inhibitor donepezil delays loss of ADL abilities. A similar
"time to substantial loss" approach was used by Sano et al in the use of
selegiline and tocopherol. Bodick et al report about the clinical
efficacy of the muscarinic agonist xanomeline on cognitive function, ADL
and disturbing behaviors, although gastro-intestinal side-effects and syncope
at therapeutic dose caused many drop-outs. Negative results regarding the
efficacy of linopirdine, an acetylcholine releasing agent, were reported
by Rockwood et al. These results are compounded by the fact that participation
in clinical trials per se has a therapeutic benefit, as demonstrated by
Albert et al. |
(NEUROLOGY 1997;48:PA100)
| LAWRENCE FRIEDHOFF, SHARON L. ROGERS, TEANECK, NJ |
Sorry, |
(N ENGL J MED 1997;336:1216-1222)
| MARY SANO, PHD, CHRISTOPHER ERNESTO, MS, RONALD G. THOMAS, PHD, MELVILLE R. KLAUBER, PHD,ET AL, FOR THE MEMBERS OF THE ALZHEIMER'S DISEASE COOPERATIVE STUDY, VARIOUS CENTRES, USA |
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(ARCH NEUROL 1997;54:465-473)
| NEIL C. BODICK, MD,
PHD, WALTER W. OFFEN, PHD, ALLAN I. LEVEY, MD, PHD, NEAL R. CUTLER, MD, ET AL, VARIOUS CENTRES, USA VERDUN, QC |
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(CAN J NEUROL SCI 1997;24:140-145)
| KENNETH ROCKWOOD, B. LYNN BEATTIE, M. ROBIN EASTWOOD, HOWARD FELDMAN, ET AL, VARIOUS CENTRES, CANADA |
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(NEUROLOGY 1997;49:38-43)
| S.M. ALBERT, PHD, M. SANO, PHD, K. MARDER, MD, D.M. JACOBS, PHD, ET AL, NEW YORK, NY, BALTIMORE, MD, BOSTON, MA |
To view abstract in
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(JAMA 1997;277:1380-1386)
| SIMIN NIKBIN MEYDANI,
DVM, PHD, MOHSEN MEYDANI, DVM, PHD, JEFFREY B. BLUMBERG, PHD, LYNETTE S. LEKA, ET AL, BOSTON, MA |
To view abstract in
PubMed |
