May 2001

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IN THIS
ISSUE

UPDATE ON THE CCCD

  • Guidelines help neurologists face new diagnostic challenges
  • Assessment is indicated when patients complain of memory lapses
  • Depressive syndromes in dementia should be treated
  • Quality of life can be improved with BPSD management

MILD COGNITIVE IMPAIRMENT

  • Diagnostic criteria for incipient dementia needs improvement
  • MCI most often represents early-stage Alzheimer's disease
  • Guidelines for monitoring MCI are available

FAMILY INTERVENTIONS FOR CAREGIVERS

  • Intervention helps both caregivers and patients

BEHAVIOUR THERAPY VS PHARMACOTHERAPY

  • Various treatments evoked modest reductions in agitation

EFFECT OF BEHAVIOURAL DISTURBANCES ON ADL

  • Behavioural disturbances in AD contribute significantly to AD disability
  • Frontal lobe behaviours strongly contribute to failures of instrumental ADLs
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EDITORIAL
COMMENT

UPDATE ON THE CCCD
The guidelines from the Canadian Consensus Conference on Dementia (CCCD) regarding diagnosis and management of dementia have been updated and published in a supplement to the Canadian Journal of Neurological Sciences. Representative abstracts relevant to screening and assessment of early symptoms are included in this issue of International Abstracts in Alzheimer's Disease & Other Dementias (Chertkow et al, Patterson & Gass), as well as abstracts relevant to depression and other psychiatric symptoms associated with dementia (Thorpe & Groulx, Herrmann). Although primarily targeted to family practitioners, these guidelines are useful to all health professionals who treat persons with dementia.

Assessment of suspected dementia

(CAN J NEUROL SCI 2001;28:SUPPL1 - S27-S41)


H. CHERTKOW,
H. BERGMAN,
H.M. SCHIPPER,
S. GAUTHIER,
ET AL,
MONTREAL, QC,
JERUSALEM, ISRAEL

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Screening for cognitive impairment and dementia in the elderly

(CAN J NEUROL SCI 2001;28: SUPPL1 - S42-S51)


CHRISTOPHER J.S. PATTERSON,
DAVID A. GASS,
HAMILTON, ON,
HALIFAX, NS

Sorry, this abstract is unavailable


Depressive syndromes in dementia

(CAN J NEUROL SCI 2001;228: SUPPL1 - S83-S95)


LILIAN THORPE,
BERNARD GROULX,
SASKATOON, SK,
MONTREAL, QC

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Recommendations for the management of behavioral
and psychological symptoms of dementia

(CAN J NEUROL SCI 2001;28: SUPPL. 1 ð S96-S107)


NATHAN HERRMANN,
NORTH YORK, ON

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MILD COGNITIVE IMPAIRMENT

EDITORIAL
COMMENT

The group of patients with subjective and objective memory decline but no dementia is attracting a lot of interest as an incipient stage of Alzheimer's disease, possibly amenable to early therapy with agents such as tocopherol, donepezil, rivastigmine, galantamine, old NSAIDs and new COX-2 selective inhibitors. The natural history of what is now being called 'amnestic MCI' is being reported from France (Ritchie et al ) and the U.S. (Morris et al ). New consensus guidelines, such as the ones proposed by Peterson et al, are needed to manage the increasing number of persons consulting physicians for their MCI.

Classification criteria for mild cognitive impairment:
a population-based validation study

(NEUROLOGY 2001;56:37-42)


KAREN RITCHI, PHD,
SYLVAINE ARTERO, MA,
JACQUES TOUCHON, MD,
MONTPELLIER, FRANCE

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Mild cognitive impairment represents early-stage Alzheimer disease

(ARCH NEUROL 2001;58:397-405)


JOHN C. MORRIS, MD,
MARTHA STORANDT, PHD,
J. PHILIP MILLER,
DANIEL W. MCKEEL, MD,
ET AL,
ST. LOUIS, MO

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Practice parameter: early detection of dementia: mild cognitive
impairment (an evidence-based review) -- Report of the Quality
Standards Subcommittee of the American Academy of Neurology

(NEUROLOGY 2001;56:1133-1142)


R.C. PETERSEN, PHD, MD,
J.C. STEVENS, MD,
M. GANGULI, MD, MPH,
E.G. TANGALOS, MD,
ET AL,
ROCHESTER, MN,
PITTSBURGH, PA,
LOS ANGELES, CA

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FAMILY INTERVENTIONS FOR CAREGIVERS


EDITORIAL
COMMENT
Reducing caregiver burden is increasingly recognized as being an essential component of management for dementia. In this randomized controlled trial, Marriott et al use a cognitive-behavioural intervention including carer education, stress management and coping skills training to determine benefit for caregivers and patients. Caregivers who received the intervention demonstrated significantly less distress and depression than controls. More surprisingly, behavioural disturbances in the dementia patients were also significantly reduced.

Effectiveness of cognitive-behavioural family intervention in reducing
the burden of care in carers of patients with Alzheimer's disease

(BR J PSYCHIATRY 2000;176:557-562)


A. MARRIOTT,
C. DONALDSON,
N. TARRIER,
A. BURNS,
MANCHESTER, UK

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BEHAVIOUR THERAPY VS PHARMACOTHERAPY

EDITORIAL
COMMENT
The relative strengths and weaknesses of behavioural approaches vs pharmacotherapy for the treatment of behavioural disturbances in dementia has long been debated, hampered by a lack of head-to-head studies. In a randomized, placebo-controlled trial comparing haloperidol, trazodone, behavioural management or placebo in behaviourally disturbed outpatients, none of the active treatments were significantly better than placebo. The debate continues...

Treatment of agitation in AD: a randomized, placebo-controlled clinical trial

(NEUROLOGY 2000;55:1271-1278)


L. TERI, PHD,
R.G. LOGSDON, PHD,
E. PESKIND, MD,
ET AL,
VARIOUS CENTRES, USA

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EFFECT OF BEHAVIOURAL DISTURBANCES ON ADL

EDITORIAL
COMMENT

While it has usually been thought that cognitive dysfunction is the cause of impaired activities of daily living (ADL), studies by Tekin et al and Norton et al examined the effect of behavioural disturbances on instrumental ADL. Results suggest that not only does behaviour have significant effects on ADL, but that certain types of behaviours, such as those related to frontal lobe systems, are particularly important.

Activities of daily living in Alzheimer's disease:
neuropsychiatric, cognitive, and medical illness influences

(AM J GERIATR PSYCHIATRY 2001;9:81-86)


SIBEL TEKIN, MD,
LYNN A. FAIRBANKS, PHD,
SUSAN O'CONNOR, RN,
SUSAN ROSENBERG, RN,
JEFFREY L. CUMMINGS, MD,
LOS ANGELES, CA

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The impact of behavioral symptoms on Activities
of Daily Living in patients with dementia

(AM J GERIATR PSYCHIATRY 2001;9:41-48)


LAUREN E. NORTON, PHD,
PAUL F. MALLOY, PHD,
STEPHEN SALLOWAY, MD, MS,
BOSTON, MA

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